Gene Synthesis & Cloning
- De novo synthesis up to 10 kb
- Codon optimisation available
Research Services
Full-spectrum bioservices from experimental design through to data delivery, with a PhD-level scientist as your direct contact. For Research Use Only, not intended for clinical, therapeutic, or diagnostic applications.
Service 01
Plasmids
Custom-designed, sequence-verified plasmids tailored to your experimental requirements.
Vector Engineering
- Custom backbone modification
- Promoter selection and tag insertion
Mutagenesis
- Site-directed, deletion, insertion
- 100% sequence confirmation
Scale-Up Production
- Microgram to milligram quantities
- Endotoxin-free options
Quality Verification
- Full-length Sanger sequencing
- Restriction digest verification
Documentation Package
- Sequencing chromatograms
- Vector maps and QC reports
Off the shelf
Ready-to-Use Plasmid Portfolio
Immediate access to commonly used vectors, without the wait.
Expression Vectors
Mammalian, bacterial and yeast expression systems with diverse promoter and tag options.
CRISPR Plasmids
Cas9, Cas12a and base editor vectors with gRNA cloning sites.
Reporter Constructs
Fluorescent and luminescent reporters for promoter assays, cell labelling and in vivo imaging.
Viral Packaging Plasmids
Optimised helper plasmids for adeno-associated virus, lentivirus and retrovirus production.
All catalogue plasmids are pre-verified by full-length sequencing and supplied with annotated vector maps. Bulk orders and custom aliquoting are available for core facilities and screening centres.
Service 02
Viral Vectors
End-to-end solutions from vector design to high-titer viral particle production.
1
Virus Packaging Services
Custom production of adeno-associated virus, lentivirus and retrovirus at research to pre-clinical scales.
2
Ready-to-Use AAV & LV
Off-the-shelf catalogue of validated adeno-associated virus serotypes and lentiviral particles.
3
Rabies Virus Tools
Specialised retrograde and anterograde tracing vectors for neuroscience applications.
4
Capsid Engineering
Directed evolution services for novel adeno-associated virus capsid discovery with enhanced tropism.
Vector systems
AAV, LV & RV solutions
Validated vector systems for gene delivery, stable line generation and neural circuit mapping.
Adeno-associated virusAAV
Peak titers of
1013 GC/mL
1013 GC/mL
- Stringent purity validation on every lot
- Serotypes 1, 2, 5, 6, 8, 9, DJ and custom variants
- Ideal for in vivo gene delivery, optogenetics and chemogenetics
LentivirusLV
Broad tropism via
VSV-G pseudotyping
VSV-G pseudotyping
- Custom pseudotyping available on request
- High-efficiency transduction of dividing and non-dividing cells
- Stable cell line generation, shRNA library screening and ex vivo work
Rabies virusRV
Monosynaptic
retrograde tracing
retrograde tracing
- A core technique for neural circuit mapping
- EnvA-pseudotyped vectors for cell-type-specific labelling
- G-deleted design for trans-synaptic tracing with minimal cytotoxicity
Capsid discovery
Capsid-Directed Evolution
Discovery of novel adeno-associated virus capsids with enhanced tissue specificity and transduction efficiency, from libraries exceeding 107 variants.
1
Library Generation
Error-prone PCR, DNA shuffling and peptide insertion libraries exceeding 107 variants.
2
Selection Strategies
In vivo and in vitro selection rounds tailored to your target tissue or cell type.
3
Bioinformatics Analysis
NGS-based enrichment tracking and variant identification.
4
Validation
Top candidates packaged with reporter constructs and validated in your model system.
Service 03
Organoids
Patient-relevant 3D culture models that recapitulate tissue architecture and function.
1
Organoid Establishment
Derivation from primary tissue biopsies, iPSCs or adult stem cells.
2
Characterisation
Immunofluorescence, gene expression profiling and functional assays.
3
Scalable Culture
From 96-well format for screening through to large-scale production.
Supported tissue types: intestinal · hepatic · cerebral · renal · tumor
In-house screening
Organoid-Based Drug Screening
Physiologically relevant models that bridge the gap between 2D cell lines and animal models.
Viability & Toxicity Assays
- ATP-based luminescence
- LDH release
- Caspase activation in 3D
High-Content Imaging
- Automated confocal imaging
- Morphological analysis
- Marker expression quantification
Dose-Response Curves
- IC50 and EC50 determination
- Multiple organoid lines in parallel
Combination Screening
- Systematic combination evaluation
- Synergy scoring
Organoid-based screening reduces late-stage attrition through more translatable efficacy and toxicity data.
Living biobank
Organoid Library Construction
Characterised organoid lines banked for longitudinal studies and repeatable screening campaigns.
Patient-Derived Libraries
Panels established from diverse patient cohorts for population-level drug response studies.
Cryopreservation & Recovery
Validated freezing protocols with high post-thaw viability and preserved phenotype.
Database Integration
Each line annotated with clinical metadata, genomic characterisation and culture parameters.
Quality Control
STR authentication, mycoplasma testing and morphology verification for every banked line.